Pharmacokinetic interaction of rifapentine and raltegravir in healthy volunteers
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic interaction of rifapentine and raltegravir in healthy volunteers.
OBJECTIVES Latent tuberculosis infection and tuberculosis disease are prevalent worldwide. However, antimycobacterial rifamycins have drug interactions with many antiretroviral drugs. We evaluated the effect of rifapentine on the pharmacokinetic properties of raltegravir. METHODS In this open-label, fixed-sequence, three-period study, 21 healthy volunteers were given: raltegravir alone (400 m...
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BACKGROUND Ranitidine is a histamine 2 receptor antagonist, and daijokito is a Kampo (Chinese herbal medicine as practiced in Japan) formula, which is traditionally used for treating constipation and digestive trouble. Previous study demonstrated that daijokito significantly affected the pharmacokinetics of ranitidine in rats; however, the doses of ranitidine and daijokito in that study were hi...
متن کاملPharmacokinetic and safety profile of raltegravir and ribavirin, when dosed separately and together, in healthy volunteers.
BACKGROUND Treatment of chronic hepatitis C virus (HCV) infection in HIV-1-co-infected individuals remains challenging due to numerous factors, including drug-drug interactions. The aim of this study was to assess the safety and pharmacokinetic (PK) profile of raltegravir and ribavirin when dosed separately and together. METHODS Fourteen healthy volunteers [mean (standard deviation) age 35 (1...
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Raltegravir is a potent inhibitor of HIV integrase. Persistently high intracellular concentrations of raltegravir may explain sustained efficacy despite high pharmacokinetic variability. We performed a pharmacokinetic study of healthy volunteers. Paired blood samples for plasma and peripheral blood mononuclear cells (PBMCs) were collected predose and 4, 8, 12, 24, and 48 h after a single 400-mg...
متن کاملPharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers.
The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label, randomized, balanced, multiple-dose, three-period crossover study. Fourteen subjects received t...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2013
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkt483